Anti-CCL6 Antibody Picoband®

About this product

Boster Bio Anti-CCL6 Antibody Picoband® catalog # A30384. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A30384

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin (e.g. the immature myeloid cell lines DA3 and 32D cl3, and the macrophage cell line P388D) that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced.CCL6 can also be induced in the mouse lung by the cytokine interleukin 13. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.

Synonyms

C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6; CCL6 (22-95) ; CCL6 (23-95) ; Ccl6; C10; Scya6

Gene Name

Ccl6

Gene ID

20305

UniProt

P27784

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CCL6 recombinant protein (Position: G22-A116) .

Clonality

Polyclonal

Tissue Specificity

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

Applications

ELISA (Cap), IHC, WB

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

CCL6 (22-95) and CCL6 (23-95) are potent chemoattractants.

References & Citations

1. Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5), 403-412 (1991) . 2. Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172 (3) :1872-81.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

6374 MW

Observed Molecular Weight

11 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Chemokine (C-C motif) ligand 6

Subcellular Location

Secreted.

Protein Name

Large S protein

Isotype

Rabbit IgG

Contents

243