Anti-CCL8 Antibody

About this product

Boster Bio Anti-CCL8 Antibody Picoband® catalog # A03237-1. Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Specifications

Catalog number

A03237-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CCL8, also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. It is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.

Synonyms

C-C motif chemokine 8; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8; Ccl8; Mcp2; Scya8

Gene Name

Ccl8

Gene ID

20307

UniProt

Q9Z121

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CCL8 recombinant protein (Position: G24-P97) .

Clonality

Polyclonal

Applications

ELISA (Cap), IHC

Field of Research

Chemokines, Immunology, Innate Immunity, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity) . .

References & Citations

1. GRCh38: Ensembl release 89: ENSG00000108700 - Ensembl, May 2017. 2. Proost P, Wuyts A, Van Damme J (January 1996) . Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1. J. Leukoc. Biol. 59 (1) : 67–74. PMID 8558070.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

71 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Chemokine (C-C motif) ligand 8

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

243