Anti-CD1b Antibody Picoband®

About this product

Boster Bio Anti-CD1b Antibody Picoband® catalog # A02158-1. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02158-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD1B is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.

Synonyms

T-cell surface glycoprotein CD1b; CD1b; CD1B

Gene Name

CD1B

Gene ID

910

UniProt

P29016

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CD1b.

Clonality

Polyclonal

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Applications

IHC, WB

Field of Research

Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Non-CD

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

References & Citations

1. Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., Brenner, M. B. Recognition of a lipid antigen by CD1-restricted alpha-beta (+) T cells. Nature 372: 691-694, 1994. 2. Park, S.-H., Bendelac, A. CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000. 3. Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., Modlin, R. L. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269: 227-230, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63692 MW

Observed Molecular Weight

65 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

CD1b molecule

Subcellular Location

Cell membrane.

Protein Name

Sentrin-specific protease 1

Isotype

Rabbit IgG

Contents

243