Anti-FCGR2A Antibody Picoband®

About this product

Boster Bio Anti-FCGR2A Antibody Picoband® catalog # A01450-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01450-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene. This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. It is mapped to 1q23.3. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

Synonyms

Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD32; FCGR2A; CD32; FCG2; FCGR2A1; IGFR2

Gene Name

FCGR2A

Gene ID

2212

UniProt

P12318

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human FCGR2A recombinant protein (Position: Q34-M210) .

Clonality

Polyclonal

Tissue Specificity

Found on monocytes, neutrophils and eosinophil platelets.

Applications

ELISA (Cap), IHC, WB

Field of Research

Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Myeloid, Receptors, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

References & Citations

1. Asano, K., Matsushita, T., Umeno, J., Hosono, N., Takahashi, A., Kawaguchi, T., Matsumoto, T., Matsui, T., Kakuta, Y., Kinouchi, Y., Shimosegawa, T., Hosokawa, M., Arimura, Y., Shinomura, Y., Kiyohara, Y., Tsunoda, T., Kamatani, N., Iida, M., Nakamura, Y., Kubo, M. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nature Genet. 41: 1325-1329, 2009. 2. De Rose, V., Arduino, C., Cappello, N., Piana, R., Salmin, P., Bardessono, M., Goia, M., Padoan, R., Bignamini, E., Costantini, D., Pizzamiglio, G., Bennato, V., Colombo, C., Giunta, A., Piazza, A. Fc-gamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis.Europ. J. Hum. Genet. 13: 96-101, 2005.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51561 MW

Observed Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Fc fragment of IgG receptor IIa

Subcellular Location

Cell membrane.

Protein Name

Keratin, type I cytoskeletal 14

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.