Anti-Nova1 Antibody Picoband®

About this product

Boster Bio Anti-Nova1 Antibody Picoband® catalog # A06087-1. Tested in ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06087-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene. It is mapped to 14q12. This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Synonyms

RNA-binding protein Nova-1; Neuro-oncological ventral antigen 1; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1; NOVA1

Gene Name

NOVA1

Gene ID

4857

UniProt

P51513

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Nova1 recombinant protein (Position: T413-V506) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.

Applications

ELISA, IF, IHC, IHC-F, ICC, WB, Flow Cytometry

Field of Research

Cell Type Marker, Neuron Marker, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May regulate RNA splicing or metabolism in a specific subset of developing neurons.

References & Citations

1. Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., Yang, Y. Y. L., Darnell, R. B. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron 25: 359-371, 2000. 2. Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., Darnell, J. C., Darnell, R. B.HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature 456: 464-469, 2008. 3. Ule, J., Stefani, G., Mele, A., Ruggiu, M., Wang, X., Taneri, B., Gaasterland, T., Blencowe, B. J., Darnell, R. B. An RNA map predicting Nova-dependent splicing regulation. Nature 444: 580-586, 2006.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

80420 MW

Observed Molecular Weight

52-75 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

NOVA alternative splicing regulator 1

Subcellular Location

Nucleus.

Protein Name

MORC family CW-type zinc finger protein 3

Isotype

Rabbit IgG

Contents

243