Anti-FGF23 Antibody Picoband®

About this product

Boster Bio Anti-FGF23 Antibody Picoband® catalog # A00478-3. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00478-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fibroblast growth factor 23orFGF23is aproteinthat in humans is encoded by theFGF23gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) . Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC) .

Synonyms

Fibroblast growth factor 23; FGF-23; Fgf23

Gene Name

Fgf23

Gene ID

170583

UniProt

Q8VI82

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived rat FGF23 recombinant protein (Position: Y25-V251) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the parathyroid.

Applications

ELISA, WB

Field of Research

Cancer, Cytoskeleton/ECM, Developmental Biology, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Regulator of phosphate homeostasis (By similarity) . Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity) . Regulator of vitamin-D metabolism (By similarity) . Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity) . Acts ly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.

References & Citations

1. Entrez Gene: FGF23 fibroblast growth factor 23. 2. Fukumoto S (2008) . Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23. Intern. Med. 47 (5) : 337–43. 3. Yamashita T, Yoshioka M, Itoh N (October 2000) . Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun.277 (2) : 494–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

24145 MW

Observed Molecular Weight

35 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Fibroblast growth factor 23

Subcellular Location

Secreted.

Protein Name

Metalloproteinase inhibitor 3

Isotype

Rabbit IgG

Contents

243