Anti-Myelin oligodendrocyte glycoprotein/MOG Antibody Picoband®

About this product

Boster Bio Anti-Myelin oligodendrocyte glycoprotein/MOG Antibody Picoband® catalog # A03294. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A03294

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS) . In humans this protein is encoded by the MOG gene. This gene is mapped to 6p22.1. It is speculated to serve as a necessary adhesion molecule to provide structural integrity to the myelin sheath and is known to develop late on the oligodendrocyte. The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.

Synonyms

Myelin-oligodendrocyte glycoprotein; MOG

Gene Name

MOG

Gene ID

4340

UniProt

Q16653

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Myelin oligodendrocyte glycoprotein/MOG, which shares 85.7% and 88.6% amino acid (aa) sequence identity with mouse and rat Myelin oligodendrocyte glycoprotein/MOG, respectively.

Clonality

Polyclonal

Tissue Specificity

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Applications

Flow Cytometry, IHC, WB

Field of Research

Cancer, Lipid Metabolism, Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Mediates homophilic cell-cell adhesion (By similarity) . Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Acts as a receptor for rubella virus.

References & Citations

1. Pham-Dinh D, Della Gaspera B, Kerlero de Rosbo N, Dautigny A (September 1995) . Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms. Genomics. 2. Pham-Dinh D, Jones EP, Pitiot G, Della Gaspera B, Daubas P, Mallet J, Le Paslier D, Fischer Lindahl K, Dautigny A (1995) . 3. Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region. 4. Immunogenetics. Roth MP, Malfroy L, Offer C, Sevin J, Enault G, Borot N, Pontarotti P, Coppin H (July 1995) . 5. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. Genomics. 6. Berger, T., Innsbruck Medical University Dept. of Neurology interviewed by S. Gillooly, Nov. 24, 2008.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

26 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Myelin oligodendrocyte glycoprotein

Subcellular Location

Cell membrane. Multi-pass membrane protein. Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

243