Anti-ARA9/AIP Antibody Picoband® (monoclonal, 10G8)

About this product

Boster Bio Anti-ARA9/AIP Antibody Picoband® (monoclonal, 10G8) catalog # M02759. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

M02759

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

AIP, also known as, ARA9 or XAP-2, is a protein that in humans is encoded by the AIP gene. This gene is mapped to 11q13.2. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. It has been shown that AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein. AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA) .

Synonyms

H receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9; AIP; XAP2

Gene Name

AIP

Gene ID

9049

UniProt

O00170

Host

Mouse

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ARA9 recombinant protein (Position: D91-H330) . Human ARA9 shares 95% amino acid (aa) sequence identity with both mouse and rat ARA9.

Clonality

Monoclonal

Clone

Clone: 10G8

Tissue Specificity

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Chaperones, Neuroscience, Protein Trafficking, Sensory System, Signal Transduction, Visual System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.

References & Citations

1. Carver LA, Bradfield CA (April 1997) . Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J. Biol. Chem. 272 (17) : 11452–6. 2. Kuzhandaivelu, N., Cong, Y.-S., Inouye, C., Yang, W.-M., Seto, E. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 24: 4741-4750, 1996. 3. Occhi G, Trivellin G, Ceccato F, et al. (2010) . Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia.. Eur. J. Endocrinol. 163 (3) : 369–376.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

38 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aryl hydrocarbon receptor interacting protein

Subcellular Location

Cytoplasm

Isotype

Mouse IgG2b

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.