Anti-MR1 Antibody Picoband®

About this product

Boster Bio Anti-MR1 Antibody catalog # A00618-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00618-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene. MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome.

Synonyms

Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein; MR1

Gene Name

MR1

Gene ID

3140

UniProt

Q95460

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MR1 recombinant protein (Position: R23-D269) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

ELISA, Flow Cytometry, WB

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Developmental Biology, ECM Proteins, Extracellular Matrix, Organogenesis, Signal Transduction, Signaling Pathway, Skeletal Development, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT) . MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

References & Citations

1. Entrez Gene: MR1 major histocompatibility complex, class I-related. 2. Hashimoto K, Hirai M, Kurosawa Y (Aug 1995) . A gene outside the human MHC related to classical HLA class I genes. Science. 269 (5224) : 693–5. 3. Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998) . Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog. Biochem Biophys Res Commun. 250 (3) : 558–64.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57371 MW

Observed Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Major histocompatibility complex, class I-related

Subcellular Location

Cell membrane. Single-pass membrane protein. Extracellular side. Endoplasmic reticulum.

Protein Name

Steroid 17-alpha-hydroxylase/17,20 lyase

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.