- Catalog number
- A02378-1
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- FABP 2, Fatty acid-binding protein 2, is a protein that in humans is encoded by the FABP2 gene. Using a human cDNA probe, the gene is assigned to chromosome 4 in somatic cell hybrids. FABP 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABPs belong to a multigene family with nearly twenty identified members. And FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. Also, they may be responsible in the modulation of cell growth and proliferation.
- Synonyms
- Fatty acid-binding protein, intestinal; Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP; Fabp2; Fabpi
- Gene Name
- Fabp2
- Gene ID
- 14079
- UniProt
- P55050
- Host
- Rabbit
- Reactivity
- Mouse
- Cross Reactivity
- No cross-reactivity with other proteins
- Immunogen
- E. coli-derived mouse FABP2/I-FABP recombinant protein (Position: A2-E132) .
- Clonality
- Polyclonal
- Tissue Specificity
- Expressed in the small intestine. Highest expression levels in the proximal ileum. .
- Applications
- ELISA
- Field of Research
- Calcium Binding Proteins, Calcium Signaling, Neuroscience, Neurotransmission
- Purification
- Immunogen affinity purified.
- Concentration
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Function
- FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. .
- References & Citations
- 1. Baier, L. J., Sacchettini, J. C., Knowler, W. C., Eads, J., Paolisso, G., Tataranni, P. A., Mochizuki, H., Bennett, P. H., Bogardus, C., Prochazka, M.An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.J. Clin. Invest. 95: 1281-1287, 1995. 2. Georgopoulos, A., Aras, O., Tsai, M. Y.Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes.J. Clin. Endocr. Metab. 85: 3155-3160, 2000. 3. Sparkes, R. S., Mohandas, T., Heinzmann, C., Gordon, J. I., Klisak, I., Zollman, S., Sweetser, D. A., Ragunathan, L., Winokur, S., Lusis, A. J.Human fatty acid binding protein assignments intestinal to 4q28-4q31 and liver to 2p11. (Abstract) Cytogenet. Cell Genet. 46: 697 only, 1987.
- Storage Conditions
- Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 15126 MW
- Observed Molecular Weight
- 15 kDa
- Specificity
- No cross reactivity with other proteins.
- Applications Notes
- ELISA Capture (Matched Antibody Pair), 2-8μg/ml
- Gene Name Synonym
- Fatty acid-binding protein, intestinal
- Subcellular Location
- Cytoplasm.
- Protein Name
- Fatty acid-binding protein, intestinal
- Isotype
- Rabbit IgG
- Contents
- Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
