Anti-MUC13 Antibody Picoband®

About this product

Boster Bio Anti-MUC13 Antibody Picoband® catalog # A02674-2. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02674-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues. It is mapped to 3q21.2. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva.

Synonyms

Mucin-13; MUC-13; Down-regulated in colon cancer 1; MUC13; DRCC1; RECC; UNQ6194; PRO20221

Gene Name

MUC13

Gene ID

56667

UniProt

Q9H3R2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MUC13 recombinant protein (Position: E226-S312) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Applications

ELISA, IF, IHC, WB

Field of Research

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

References & Citations

1. Shimamura, T., Ito, H., Shibahara, J., Watanabe, A., Hippo, Y., Taniguchi, H., Chen, Y., Kashima, T., Ohtomo, T., Tanioka, F., Iwanari, H., Kodama, T., Kazui, T., Sugimura, H., Fukayama, M., Aburatani, H. Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci. 96: 265-273, 2005. 2. Williams, S. J., Wreschner, D. H., Tran, M., Eyre, H. J., Sutherland, G. R., McGuckin, M. A. MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J. Biol. Chem. 276: 18327-18336, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

55 kDa

Observed Molecular Weight

75, 110-120 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Mucin 13, cell surface associated

Subcellular Location

Secreted. Cell membrane. Single-pass type I membrane protein. Apical cell membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.