Anti-Lamin B Receptor/LBR Antibody Picoband®

About this product

Boster Bio Anti-Lamin B Receptor/LBR Antibody Picoband® catalog # A01238-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01238-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene. It is mapped to 1q42.12. The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Synonyms

Lamin-B receptor; Integral nuclear envelope inner membrane protein; LMN2R; LBR

Gene Name

LBR

Gene ID

3930

UniProt

Q14739

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Lamin B Receptor/LBR recombinant protein (Position: H102-F209) .

Clonality

Polyclonal

Tissue Specificity

Detected in neutrophils and macrophages (at protein level) . Highly expressed in bone marrow.

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Amino Acid Metabolism, Amino Acids, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Anchors the lamina and the heterochromatin to the inner nuclear membrane.

References & Citations

1. Holmer L, Pezhman A, Worman HJ (December 1998) . The human lamin B receptor/sterol reductase multigene family. Genomics. 54 (3) : 469–76. 2. Schuler E, Lin F, Worman HJ (April 1994) . Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane. The Journal of Biological Chemistry.269 (15) : 11312–7.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

123799 MW

Observed Molecular Weight

65-71 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Lamin B receptor

Subcellular Location

Nucleus inner membrane. Multi-pass membrane protein.

Protein Name

Vinculin

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.