Anti-LMTK3 Antibody Picoband®

About this product

Boster Bio Anti-LMTK3 Antibody Picoband® catalog # A08432-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A08432-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lemur tyrosine kinase 3 is a protein that in humans is encoded by the LMTK3 gene. It is mapped to 19q13.33. LMTK3 (lemur tyrosine kinase 3), also known as LMR3 or TYKLM3, is a 1,460 amino acid protein that contains one protein kinase domain. One of several members of the protein kinase superfamily, LMTK3 is expressed at low levels in brain and testis where it catalyzes the ATP-dependent phosphorylation of target proteins, thereby modifying their function.

Synonyms

Serine/threonine-protein kinase LMTK3; Lemur tyrosine kinase 3; LMTK3; KIAA1883; TYKLM3

Gene Name

LMTK3

Gene ID

114783

UniProt

Q96Q04

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human LMTK3 recombinant protein (Position: S1317-D1382) .

Clonality

Polyclonal

Applications

ELISA, IHC, WB

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels inly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.

References & Citations

1. Hanks, S.K. and Quinn, A.M. 1991. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200: 38-62. 2. Nagase, T., Kikuno, R. and Ohara, O. 2001. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res. 8: 179-187.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

153 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Lemur tyrosine kinase 3

Subcellular Location

Golgi apparatus membrane. Membrane. Single-pass membrane protein. Axon. Dendrite.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.