Anti-Metabotropic glutamate receptor 2/GRM2 Antibody Picoband®

About this product

Boster Bio Anti-Metabotropic glutamate receptor 2/GRM2 Antibody catalog # A06123-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06123-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Metabotropic glutamate receptor 2  (mGluR2) is a  protein  that, in humans, is encoded by the  GRM2  gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B, MGLUR2

Gene Name

GRM2

Gene ID

2912

UniProt

Q14416

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Metabotropic glutamate receptor 2/GRM2 recombinant protein (Position: N439-A710) .

Clonality

Polyclonal

Tissue Specificity

Detected in brain cortex (at protein level) . Widely expressed in different regions of the adult brain as well as in fetal brain.

Applications

ELISA, IHC, WB, Flow Cytometry

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

References & Citations

1. Flor PJ, Lindauer K, Püttner I, Rüegg D, Lukic S, Knöpfel T, Kuhn R (April 1995) . Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. The European Journal of Neuroscience. 7 (4) : 622–9. 2. Kammermeier PJ, Davis MI, Ikeda SR (January 2003) . Specificity of metabotropic glutamate receptor 2 coupling to G proteins. Molecular Pharmacology. 63 (1) : 183–91. 3. Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AF (November 2017) . mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

17828 MW

Observed Molecular Weight

100 kDa, >200 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glutamate metabotropic receptor 2

Subcellular Location

Mitochondrion inner membrane.

Protein Name

Delta-1-pyrroline-5-carboxylate synthase

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.