Anti-Fascin 2/FSCN2 Antibody Picoband®

About this product

Boster Bio Anti-Fascin 2/FSCN2 Antibody Picoband® catalog # A07840-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07840-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fascin-2 is a protein that in humans is encoded by the FSCN2 gene. It is mapped to 17q25.3. This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Fascin-2; Retinal fascin; FSCN2

Gene Name

FSCN2

Gene ID

25794

UniProt

O14926

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Fascin 2/FSCN2 recombinant protein (Position: M1-K167) .

Clonality

Polyclonal

Tissue Specificity

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Applications

ELISA, WB

Field of Research

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

References & Citations

1. Hillier LD, Lennon G, Becker M, et al. (1997) . Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 6 (9) : 807–28. 2. Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000) . Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. Genomics. 65 (2) : 146–56. 3. Saishin Y, Ishikawa R, Ugawa S, et al. (2000) . Retinal fascin: functional nature, subcellular distribution, and chromosomal localization. Invest. Ophthalmol. Vis. Sci. 41 (8) : 2087–95.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

49229 MW

Observed Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Fascin actin-bundling protein 2, retinal

Subcellular Location

Nucleus.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.