Anti-NAT8L Antibody Picoband®

About this product

Boster Bio Anti-NAT8L Antibody Picoband® catalog # A07393-2. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07393-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

N-acetyltransferase (NAT) is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines, arylhydroxylamines and arylhydrazines. It is mapped to 4p16.3. This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia) .

Synonyms

N-acetylaspartate synthetase; NAA synthetase; Camello-like protein 3; N-acetyltransferase 8-like protein; NAT8L; CML3

Gene Name

NAT8L

Gene ID

339983

UniProt

Q8N9F0

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human NAT8L, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain.

Applications

Flow Cytometry, WB

Field of Research

Interleukins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.

References & Citations

1. Evans DA (1989) . N-acetyltransferase. Pharmacology & Therapeutics. 42 (2) : 157–234. 2. Ma Y, Ghoshdastider U, Wang J, Ye W, Dötsch V, Filipek S, Bernhard F, Wang X (2012) . Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening. Protein Expr. Purif. 86 (2) : 120–6. 3. Sim, Edith; Lack, Nathan; Wang, Chan-Ju; et al. (May 2008) . Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms. Toxicology. 254 (3) : 170–183.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

108320 MW

Observed Molecular Weight

33 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

N-acetyltransferase 8 like

Subcellular Location

Apical cell membrane. Basolateral cell membrane. Microvillus membrane. Secreted.

Protein Name

Gamma-aminobutyric acid type B receptor subunit 1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.