Anti-SMC4 Antibody Picoband®

About this product

Boster Bio Anti-SMC4 Antibody Picoband® catalog # A04887-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04887-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2.

Synonyms

Structural maintenance of chromosomes protein 4; SMC protein 4; SMC-4; Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog; SMC4; CAPC, SMC4L1

Gene Name

SMC4

Gene ID

10051

UniProt

Q9NTJ3

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SMC4 recombinant protein (Position: K911-C1288) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Higher expression in testis, colon, thymus.

Applications

ELISA, Flow Cytometry, IF, ICC, WB

Field of Research

Organelles, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

References & Citations

1. Hirano T (2002) . The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair. Genes Dev. 16 (4) : 399–414. 2. Ball Jr AR, Yokomori K (2001) . The structural maintenance of chromosomes (SMC) family of proteins in mammals. Chromosome Res. 9 (2) : 85–96. 3. Kimura K, Cuvier O, Hirano T (2001) . Chromosome condensation by a human condensin complex in Xenopus egg extracts. J. Biol. Chem. 276 (8) : 5417–20.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35883 MW

Observed Molecular Weight

180 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Structural maintenance of chromosomes 4

Subcellular Location

Endoplasmic reticulum membrane. Multi-pass membrane protein

Protein Name

Annexin A4

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.