Anti-GLUT9/SLC2A9 Antibody Picoband®

About this product

Boster Bio Anti-GLUT9/SLC2A9 Antibody Picoband® catalog # A02245. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02245

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Solute carrier family 2, facilitated glucose transporter member 9, also known as SLC2A9, is a protein that in humans is encoded by the SLC2A9 gene. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. This gene is mapped to 4p16.1. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. This gene transports urate and fructose. It may have a role in the urate reabsorption by proximal tubules. This gene also transports glucose at low rate.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter; SLC2A9; GLUT9

Gene Name

SLC2A9

Gene ID

56606

UniProt

Q9NRM0

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human GLUT9/SLC2A9 recombinant protein (Position: R7-P540) .

Clonality

Polyclonal

Tissue Specificity

Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level) .

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.

References & Citations

1. Chiba, T., Matsuo, H., Nagamori, S., Nakayama, A., Kawamura, Y., Shimizu, S., Sakiyama, M., Hosoyamada, M., Kawai, S., Okada, R., Hamajima, N., Kanai, Y., Shinomiya, N. Identification of a hypouricemia patient with SLC2A9 R380W, a pathogenic mutation for renal hypouricemia type 2. Nucleosides Nucleotides Nucleic Acids 33: 261-265, 2014. 2. Dinour, D., Gray, N. K., Campbell, S., Shu, X., Sawyer, L., Richardson, W., Rechavi, G., Amariglio, N., Ganon, L., Sela, B.-A., Bahat, H., Goldman, M., Weissgarten, J., Millar, M. R., Wright, A. F., Holtzman, E. J. Homozygous SLC2A9 mutations cause severe renal hypouricemia. J. Am. Soc. Nephrol. 21: 64-72, 2010. 3. Dinour, D., Gray, N. K., Ganon, L., Knox, A. J. S., Shalev, H., Sela, B.-A., Campbell, S., Sawyer, L., Shu, X., Valsamidou, E., Landau, D., Wright, A. F., Holtzman, E. J. Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. Nephrol. Dial. Transplant. 27: 1035-1041, 2012.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

59 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 2 (facilitated glucose transporter), member 9

Subcellular Location

Basolateral cell membrane. Multi-pass membrane protein. Plasma membrane. Apical cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein.

Protein Name

Solute carrier family 2, facilitated glucose transporter member 9

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.