Anti-FDPS/FPS Picoband® Antibody

About this product

Boster Bio Anti-FDPS/FPS Picoband® Antibody catalog # A01782-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01782-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 1q22. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E) -farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; FDPS; FPS; KIAA1293

Gene Name

FDPS

Gene ID

2224

UniProt

P14324

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human FDPS/FPS recombinant protein (Position: S29-Q397) .

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Immunoglobulins, Immunology, Nuclear Import/Export, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

References & Citations

1. Heinzmann, C., Clarke, C. F., Klisak, I., Mohandas, T., Sparkes, R. S., Edwards, P. A., Lusis, A. J. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics 5: 493-500, 1989. 2. Krisans, S. K., Ericsson, J., Edwards, P. A., Keller, G. A. Farnesyl-diphosphate synthase is localized in peroxisomes. J. Biol. Chem. 269: 14165-14169, 1994. 3. Scott, A. F. Personal Communication. Baltimore, Md. 11/9/2006.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57862 MW

Observed Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.25-0.5μg/mL, Human<br> Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human<br> ELISA, 0.1-0.5μg/mL, -<br>

Gene Name Synonym

Farnesyl diphosphate synthase

Subcellular Location

Cytoplasm.

Isotype

Rabbit IgG

Contents

243