Anti-FOXE1 Picoband® Antibody

About this product

Boster Bio Anti-FOXE1 Picoband® Antibody catalog # A02831-5. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02831-5

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Forkhead box protein E1 is a protein that in humans is encoded by the FOXE1 gene. It is mapped to 9q22.33. This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4.

Synonyms

Forkhead box protein E1; Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2; TTF-2; FOXE1; FKHL15; FOXE2; TITF2; TTF2

Gene Name

FOXE1

Gene ID

2304

UniProt

O00358

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human FOXE1 recombinant protein (Position: M1-M373) .

Clonality

Polyclonal

Tissue Specificity

Expressed at low levels in the more differentiated suprabasal regions of the small intestine, and at higher levels in the colon, mainly in the upper region and in scattered cells throughout the remaining epithelium. Also expressed in epithelial cells of bladder, ileum and stomach and at lower levels in pancreas and earskin. The phosphorylated form is nearly exclusively expressed in goblet cells of the small intestine and in the lumen-proximal cells of the colon (at protein level) . Also expressed in jejunum and duodenum.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Cell Biology, Co-Activators/Co-Repressors, Epigenetics and Nuclear Signaling, Nuclear Receptors, Nuclear Signaling Pathways, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Transcription, Transcription Factors, Ubiquitin & Ubiquitin Like Modifiers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May inly play a role in cell growth and migration through the regulation of WNT5A expression.

References & Citations

1. Carre, A., Castanet, M., Sura-Trueba, S., Szinnai, G., Van Vliet, G., Trochet, D., Amiel, J., Leger, J., Czernichow, P., Scotet, V., Polak, M. Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis. Hum. Genet. 122: 467-476, 2007. 2. Trueba, S. S., Auge, J., Mattei, G., Etchevers, H., Martinovic, J., Czernichow, P., Vekemans, M., Polak, M., Attie-Bitach, T. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations. J. Clin. Endocr. Metab. 90: 455-462, 2005. 3. Venza, I., Visalli, M., Parrillo, L., De Felice, M., Teti, D., Venza, M. MSX1 and TGF-beta-3 are novel target genes functionally regulated by FOXE1. Hum. Molec. Genet. 20: 1016-1025, 2011.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

38 kDa

Observed Molecular Weight

38 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Forkhead box E1

Subcellular Location

Nucleus.

Protein Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Isotype

Rabbit IgG

Contents

243