Anti-GP2 Picoband® Antibody

About this product

Boster Bio Anti-GP2 Picoband® Antibody catalog # A06630-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06630-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene. It is mapped to 7 F2; 7 63.88 cM. This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD) . Alternative splicing results in multiple transcript variants.

Synonyms

Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; Gp2

Gene Name

Gp2

Gene ID

67133

UniProt

Q9D733

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse GP2 recombinant protein (Position: S35-R497) .

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.

Applications

WB, IHC, Flow Cytometry, ELISA

Field of Research

Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

References & Citations

1. Fukuoka, S.-I., Freedman, S. D., Scheele, G. A. A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. Proc. Nat. Acad. Sci. 88: 2898-2902, 1991. 2. Fukuoka, S.-I., Freedman, S. D., Yu, H., Sukhatme, V. P., Scheele, G. A. GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Proc. Nat. Acad. Sci. 89: 1189-1193, 1992. Note: Erratum: Proc. Nat. Acad. Sci. 89: 3669 only, 1992. 3. Fukuoka, S.-I., Suzuki, M., Okabayashi, K., Takahashi, E. Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. Cytogenet. Cell Genet. 79: 231-232, 1997.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

104553 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glycoprotein 2 (zymogen granule membrane)

Subcellular Location

Cell membrane. GPI-anchor. Secreted.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

243