Anti-CD168/HMMR Picoband® Antibody

About this product

Boster Bio Anti-CD168/HMMR Picoband® Antibody catalog # A05056-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A05056-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene. It is mapped to 5q34. The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Synonyms

Hyaluronan mediated motility receptor; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD168; HMMR; IHABP; RHAMM

Gene Name

HMMR

Gene ID

3161

UniProt

O75330

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CD168/HMMR recombinant protein (Position: K5-D686) .

Clonality

Polyclonal

Tissue Specificity

May be up-regulated in bone metastatic breast cancer cells.

Applications

ELISA, Flow Cytometry, IF, ICC, WB

Field of Research

Cell Type Marker, Cytoplasmic, Intracellular, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Nuclear, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for hyaluronic acid (HA) . Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis.

References & Citations

1. Pujana, M. A., Han, J.-D. J., Starita, L. M., Stevens, K. N., Tewari, M., Ahn, J. S., Rennert, G., Moreno, V., Kirchhoff, T., Gold, B., Assmann, V., ElShamy, W. M., and 22 others. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nature Genet. 39: 1338-1349, 2007. 2. Savani, R. C., Wang, C., Yang, B. H., Zhang, S. W., Kinsella, M. G., Wight, T. N., Stern, R., Nance, D. M., Turley, E. A. Migration of bovine aortic smooth muscle cells after wounding injury: the role of hyaluronan and RHAMM. J. Clin. Invest. 95: 1158-1168, 1995. 3. Spicer, A. P., Roller, M. L., Camper, S. A., McPherson, J. D., Wasmuth, J. J., Hakim, S., Wang, C., Turley, E. A., McDonald, J. A. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. Genomics 30: 115-117, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39125 MW

Observed Molecular Weight

84 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Hyaluronan mediated motility receptor

Subcellular Location

Cell surface. Cytoplasm.

Protein Name

RNA-binding protein Musashi homolog 1

Isotype

Rabbit IgG

Contents

243