Anti-beta 3 Adrenergic Receptor/ADRB3 Antibody Picoband®

About this product

Boster Bio Anti-beta 3 Adrenergic Receptor/ADRB3 Antibody Picoband® catalog # A02104-3. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02104-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is mapped to 8p11.23. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.

Synonyms

Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; ADRB3; ADRB3R; B3AR

Gene Name

ADRB3

Gene ID

155

UniProt

P13945

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human beta 3 Adrenergic Receptor/ADRB3 recombinant protein (Position: R179-S250) .

Clonality

Polyclonal

Tissue Specificity

Expressed mainly in adipose tissues.

Applications

ELISA, IF, ICC, WB

Field of Research

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

References & Citations

1. Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., Lowell, B. B. Beta-AR signaling required for diet-induced thermogenesis and obesity resistance. Science 297: 843-845, 2002. 2. Buettner, R., Schaffler, A., Arndt, H., Rogler, G., Nusser, J., Zietz, B., Enger, I., Hugl, S., Cuk, A., Scholmerich, J., Palitzsch, K.-D. The trp64arg polymorphism of the beta-3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. J. Clin. Endocr. Metab. 83: 2892-2897, 1998. 3. Cagliani, R., Fumagalli, M., Pozzoli, U., Riva, S., Comi, G. P., Torri, F., Macciardi, F., Bresolin, N., Sironi, M. Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Am. J. Hum. Genet. 85: 64-75, 2009.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51990 MW

Observed Molecular Weight

44 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Adrenoceptor beta 3

Subcellular Location

Cell membrane. Multi-pass membrane protein.

Protein Name

Angiotensinogen

Isotype

Rabbit IgG

Contents

243