Anti-IL3RA/CD123 Antibody Picoband®

About this product

Boster Bio Anti-IL3RA/CD123 Antibody Picoband® catalog # A04307. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04307

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene. It is mapped to Xp22.33 and Yp11.2. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

Synonyms

Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123; IL3RA; IL3R

Gene Name

IL3RA

Gene ID

3563

UniProt

P26951

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human IL3RA/CD123 recombinant protein (Position: T111-T378) .

Clonality

Polyclonal

Tissue Specificity

Brain.

Applications

ELISA, Flow Cytometry, IHC, WB

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

This is a receptor for interleukin-3.

References & Citations

1. Itoh, N., Yonehara, S., Schreurs, J., Gorman, D. M., Maruyama, K., Ishii, A., Yahara, I., Arai, K., Miyajima, A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science 247: 324-327, 1990. 2. Kitamura, T., Sato, N., Arai, K., Miyajima, A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta-subunit for the human IL-3 and GM-CSF receptors. Cell 66: 1165-1174, 1991. 3. Kosugi, H., Nakagawa, Y., Hotta, T., Saito, H., Miyajima, A., Arai, K., Yokota, T. Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor. Biochem. Biophys. Res. Commun. 208: 360-367, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 3 receptor subunit alpha

Subcellular Location

Membrane. Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

243