Anti-Alas1 Antibody Picoband®

About this product

Boster Bio Anti-Alas1 Antibody Picoband® catalog # A10405-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A10405-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

Gene Name

ALAS1

Gene ID

211

UniProt

P13196

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Alas1 recombinant protein (Position: M1-Q244) .

Clonality

Polyclonal

Tissue Specificity

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

References & Citations

1. Astrin, K. H., Bishop, D. F. Assignment of human erythroid delta-aminolevulinate synthase (ALAS2) to the X chromosome. (Abstract) Cytogenet. Cell Genet. 51: 953-954, 1989. 2. Bawden, M. J., Borthwick, I. A., Healy, H. M., Morris, C. P., May, B. K., Elliott, W. H. Sequence of human 5-aminolevulinate synthase cDNA. Nucleic Acids Res. 15: 8563 only, 1987. 3. Bishop, D. F., Henderson, A. S., Astrin, K. H. Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome. Genomics 7: 207-214, 1990.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

70,581 MW

Observed Molecular Weight

71 kDa

Applications Notes

6

Gene Name Synonym

Pre T cell antigen receptor alpha

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.