Anti-HDAC9 Antibody Picoband®

About this product

Boster Bio Anti-HDAC9 Antibody Picoband® catalog # A02177-4. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02177-4

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Synonyms

Probetacellulin; Betacellulin; BTC; BTC

Gene Name

HDAC9

Gene ID

9734

UniProt

Q9UKV0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human HDAC9 recombinant protein (Position: S7-Q469) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in testis.

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Cancer, Growth Factors, Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

References & Citations

1. Mejat, A., Ramond, F., Bassel-Duby, R., Khochbin, S., Olson, E. N., Schaeffer, L. Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression. Nature Neurosci. 8: 313-321, 2005. 2. Sparrow, D. B., Miska, E. A., Langley, E., Reynaud-Deonauth, S., Kotecha, S., Towers, N., Spohr, G., Kouzarides, T., Mohun, T. J. MEF-2 function is modified by a novel co-repressor, MITR. EMBO J. 18: 5085-5098, 1999. 3. Zhou, X., Marks, P. A., Rifkind, R. A., Richon, V. M. Cloning and characterization of a histone deacetylase, HDAC9. Proc. Nat. Acad. Sci. 98: 10572-10577, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63692 MW

Observed Molecular Weight

150 kDa

Applications Notes

6

Gene Name Synonym

Betacellulin

Subcellular Location

Betacellulin: Secreted, extracellular space.

Protein Name

Sentrin-specific protease 1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.