Anti-Claudin 5/CLDN5 Antibody

About this product

Boster Bio Anti-Claudin 5/CLDN5 Antibody catalog # A03260-3. Tested in IF, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

A03260-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Synonyms

Thrombospondin-2; THBS2; TSP2

Gene Name

CLDN5

Gene ID

7122

UniProt

O00501

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Claudin 5/CLDN5, which shares 95% and 90% amino acid (aa) sequence identity with mouse and rat Claudin 5/CLDN5, respectively.

Clonality

Polyclonal

Tissue Specificity

High expression in invertebral disk tissue.

Applications

IHC, IF

Field of Research

Calcium Signaling, Calmodulin Pathway, Cardiovascular, Hypertrophy, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

References & Citations

1. Sirotkin, H., Morrow, B., Saint-Jore, B., Puech, A., Das Gupta, R., Patanjali, S. R., Skoultchi, A., Weissman, S. M., Kucherlapati, R. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. 2. Peacock RE, Keen TJ, Inglehearn CF (Mar 1998) . Analysis of a human gene homologous to rat ventral prostate.1 protein. Genomics 46 (3) : 443–9. 3. Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

130 kDa

Gene Name Synonym

Thrombospondin 2

Subcellular Location

Synapse. Postsynaptic density. Dendritic spine. Dendrite.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.