Anti-MAP4K1/HPK1 Antibody Picoband®

About this product

Boster Bio Anti-MAP4K1/HPK1 Antibody Picoband® catalog # A07909-2. Tested in WB applications. This antibody reacts with Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07909-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1) . The protein has been shown to play a role in JNK activation.

Synonyms

Fascin-2; Retinal fascin; FSCN2

Gene Name

Map4k1

Gene ID

292763

UniProt

D3Z8I4

Host

Rabbit

Reactivity

Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of rat MAP4K1/HPK1, which shares 88.2% and 100% amino acid (aa) sequence identity with human and mouse MAP4K1/HPK1, respectively.

Clonality

Polyclonal

Tissue Specificity

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Applications

WB

Field of Research

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

References & Citations

1. Hu, M. C.-T., Qiu, W. R., Wang, X., Meyer, C. F., Tan, T.-H. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev. 10: 2251-2264, 1996. 2. Kiefer, F., Tibbles, L. A., Anafi, M., Janssen, A., Zanke, B. W., Lassam, N., Pawson, T., Woodgett, J. R., Iscove, N. N. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 15: 7013-7025, 1996.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

49229 MW

Observed Molecular Weight

97 kDa

Gene Name Synonym

Fascin actin-bundling protein 2, retinal

Subcellular Location

Nucleus.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.