Anti-SLFN11 Antibody Picoband®

About this product

Boster Bio Anti-SLFN11 Antibody Picoband® catalog # A08259. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A08259

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

Synonyms

Neuropeptides B/W receptor type 1; G-protein coupled receptor 7; NPBWR1; GPR7

Gene Name

SLFN11

Gene ID

91607

UniProt

Q7Z7L1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SLFN11 recombinant protein (Position: P114-D794) .

Clonality

Polyclonal

Tissue Specificity

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.

Applications

WB, IHC, Flow Cytometry, ELISA

Field of Research

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

References & Citations

1. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., de la Casa-Esperon, E. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes, and orthopoxvirus virulence. Gene 447: 1-11, 2009. 2. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H. E., Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immun. 16: 1535-1548, 2004. 3. Gross, M. B. Personal Communication. Baltimore, Md. 11/29/2012.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

103 kDa

Applications Notes

6

Gene Name Synonym

Neuropeptides B and W receptor 1

Subcellular Location

Cell membrane. Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.