Anti-P2Y12/P2ry12 Antibody Picoband®

About this product

Boster Bio Anti-P2Y12/P2ry12 Antibody Picoband® catalog # A01136-1. Tested in Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01136-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8) . Alternative splicing results in multiple transcript variants of this gene.

Synonyms

Alpha-galactosidase A;3.2.1.22 ; Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Melibiase; Gla; Ags

Gene Name

P2ry12

Gene ID

70839

UniProt

Q9CPV9

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse P2Y12/P2ry12, which shares 73.3% and 93.3% amino acid (aa) sequence identity with human and rat P2Y12/P2ry12, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry, WB

Field of Research

Mesenchymal Stem Cells, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

References & Citations

1. Cattaneo, M., Zighetti, M. L., Lombardi, R., Martinez, C., Lecchi, A., Conley, P. B., Ware, J., Ruggeri, Z. M. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc. Nat. Acad. Sci. 100: 1978-1983, 2003. 2. Cattaneo, M. The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects. Blood 117: 2102-2112, 2011. 3. Cserep, C., Posfai, B., Lenart, N., Fekete, R., Laszlo, Z. I., Lele, Z., Orsolits, B., Molnar, G., Heindl, S., Schwarcz, A. D., Ujvari, K., Kornyei, Z., and 18 others. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science 367: 528-537, 2020.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

47643 MW

Observed Molecular Weight

40 kDa

Applications Notes

6

Gene Name Synonym

Alpha-galactosidase A

Subcellular Location

Lysosome.

Protein Name

Alpha-galactosidase A

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.