Anti-JUNB Antibody Picoband®

About this product

Boster Bio Anti-JUNB Antibody Picoband® catalog # A01825-3. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01825-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transcription factor jun-B (JUNB) is a protein that in humans is encoded by the JUNB gene. It is mapped to 19p13.2. JUNB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3', and a large fraction (over 50%) of the JUNB locus is contained in these flanking evolutionarily conserved sequences (FECS), which may be required for effecting the proper transcriptional regulation of this gene. What's more, the expression of JUNB gene might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.

Synonyms

Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; THY1

Gene Name

JUNB

Gene ID

3726

UniProt

P17275

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human JUNB, which shares 88.9% amino acid (aa) sequence identity with both mouse and rat JUNB.

Clonality

Polyclonal

Tissue Specificity

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297) . Detected in the islet of Langerhans (PubMed:21483673) .

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Neuroscience, Stem Cells, Synapse Marker, T Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

References & Citations

1. Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990) . jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell 59 (6) : 987–997. 2. Mollinedo F, Vaquerizo MJ, Naranjo JR (1991) . Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. Biochem. J. 273 (Pt 2) : 477–9. 3. Phinney DG, Tseng SW, Ryder K (1996) . Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. Genomics 28 (2) : 228–234.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

18080 MW

Observed Molecular Weight

42-45 kDa

Applications Notes

6

Gene Name Synonym

Thy-1 cell surface antigen

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Name

Thy-1 membrane glycoprotein

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.