Anti-Kinectin 1/KTN1 Antibody Picoband®

About this product

Boster Bio Anti-Kinectin 1/KTN1 Antibody Picoband® catalog # A05071-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A05071-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kinectin is a protein that in humans is encoded by the KTN1 gene. This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene.

Synonyms

Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2

Gene Name

KTN1

Gene ID

3895

UniProt

Q86UP2

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Kinectin 1/KTN1 recombinant protein (Position: K283-K827) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

References & Citations

1. Futterer, A., Kruppa, G., Kramer, B., Lemke, H., Kronke, M. Molecular cloning and characterization of human kinectin. Molec. Biol. Cell 6: 161-170, 1995. 2. Ong, L.-L., Er, C. P. N., Ho, A., Aung, M. T., Yu, H. Kinectin anchors the translation elongation factor-1-delta to the endoplasmic reticulum. J. Biol. Chem. 278: 32115-32123, 2003. 3. Plitz, T., Pfeffer, K. Intact lysosome transport and phagosome function despite kinectin deficiency. Molec. Cell. Biol. 21: 6044-6055, 2001.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

39125 MW

Observed Molecular Weight

160 kDa

Applications Notes

6

Gene Name Synonym

Matrix metallopeptidase 16

Subcellular Location

Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.

Protein Name

RNA-binding protein Musashi homolog 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.