Anti-PAR-3/PARD3 Antibody Picoband®

About this product

Boster Bio Anti-PAR-3/PARD3 Antibody Picoband® catalog # A01897-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01897-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene. This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.

Synonyms

C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1

Gene Name

PARD3

Gene ID

56288

UniProt

Q8TEW0

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PAR-3/PARD3 recombinant protein (Position: M1-Q1346) .

Clonality

Polyclonal

Tissue Specificity

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Applications

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

References & Citations

1. Chan, J. R., Jolicoeur, C., Yamauchi, J., Elliott, J., Fawcett, J. P., Ng, B. K., Cayouette, M. The polarity protein Par-3 ly interacts with p75 (NTR) to regulate myelination. Science 314: 832-836, 2006. 2. Chen, X., An, Y., Gao, Y., Guo, L., Rui, L., Xie, H., Sun, M., Lam Hung, S., Sheng, X., Zou, J., Bao, Y., Guan, H., Niu, B., Li, Z., Finnell, R. H., Gusella, J. F., Wu, B.-L., Zhang, T. Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation. Hum. Mutat. 38: 378-389, 2017. 3. Coureuil, M., Mikaty, G., Miller, F., Lecuyer, H., Bernard, C., Bourdoulous, S., Dumenil, G., Mege, R.-M., Weksler, B. B., Romero, I. A., Couraud, P.-O., Nassif, X. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science 325: 83-87, 2009.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

40895 MW

Observed Molecular Weight

151 kDa

Applications Notes

6

Gene Name Synonym

C-C chemokine receptor type 1

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.