Anti-CRTC3 Antibody Picoband®

About this product

Boster Bio Anti-CRTC3 Antibody Picoband® catalog # A04568-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04568-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene. This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Synonyms

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

Gene Name

CRTC3

Gene ID

64784

UniProt

Q6UUV7

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CRTC3 recombinant protein (Position: R116-L619) .

Clonality

Polyclonal

Tissue Specificity

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Applications

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

References & Citations

1. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.-W., McWhinnie, E., and 9 others. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Nat. Acad. Sci. 100: 12147-12152, 2003. 2. Song, Y., Altarejos, J., Goodarzi, M. O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.-H., Goode, J., Igata, M., Paz, J. C., Hogan, M. F., Singh, P. K., and 12 others. CRTC3 links catecholamine signalling to energy balance. Nature 468: 933-939, 2010. 3. Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B., Stevenson, S. C. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1-alpha transcription and mitochondrial biogenesis in muscle cells. Proc. Nat. Acad. Sci. 103: 14379-14384, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

78 kDa

Applications Notes

6

Gene Name Synonym

Chemokine (C motif) ligand 1

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.