Anti-FAAH1/FAAH Antibody Picoband®

About this product

Boster Bio Anti-FAAH1/FAAH Antibody Picoband® catalog # A00801-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00801-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fatty acid amide hydrolase or FAAH (EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.

Synonyms

Fibrinogen gamma chain; FGG; PRO2061

Gene Name

FAAH

Gene ID

2166

UniProt

O00519

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human FAAH1/FAAH recombinant protein (Position: R34-S579) .

Clonality

Polyclonal

Tissue Specificity

Detected in blood plasma (at protein level) . .

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Neurodegenerative Disease, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. .

References & Citations

1. Balsevich, G., Sticht, M., Bowles, N. P., Singh, A., Lee, T. T. Y., Li, Z., Chelikani, P. K., Lee, F. S., Borgland, S. L., Hillard, C. J., McEwen, B. S., Hill, M. N. Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proc. Nat. Acad. Sci. 115: 7605-7610, 2018. 2. Bracey, M. H., Hanson, M. A., Masuda, K. R., Stevens, R. C., Cravatt, B. F. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science 298: 1793-1796, 2002. 3. Chiang, K. P., Gerber, A. L., Sipe, J. C., Cravatt, B. F. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum. Molec. Genet. 13: 2113-2119, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

51512 MW

Observed Molecular Weight

63 kDa

Applications Notes

6

Gene Name Synonym

Fibrinogen gamma chain

Subcellular Location

Secreted .

Protein Name

Fibrinogen gamma chain

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.