Anti-IL-17A/Il17a Antibody

About this product

Boster Bio Anti-IL-17A/Il17a Antibody Picoband® catalog # A00421-3. Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Specifications

Catalog number

A00421-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Synonyms

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; Il17a; Ctla8; Il17

Gene Name

Il17a

Gene ID

301289

UniProt

Q61453

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat IL-17A/Il17a recombinant protein (Position: A18-S150) .

Clonality

Polyclonal

Tissue Specificity

Restricted to a subset of activated T-cells.

Applications

IHC, ELISA

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Ligand for IL17RA (PubMed:17911633) . The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity) . Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity) .

References & Citations

1. Entrez Gene: IL17A interleukin 17A. 2. Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993) . CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. Journal of Immunology. 150 (12) : 5445–56.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

27 kDa

Gene Name Synonym

Interleukin 17A

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.