Anti-Jagged1/JAG1 Antibody Picoband®

About this product

Boster Bio Anti-Jagged1/JAG1 Antibody Picoband® catalog # A00640-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00640-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The JAG1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Synonyms

Plasminogen activator inhibitor 1; PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1; Serpine1; Pai1; Planh1

Gene Name

JAG1

Gene ID

182

UniProt

P78504

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Jagged1/JAG1 recombinant protein (Position: A994-V1218) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Angiogenesis, Cardiovascular

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity) .

References & Citations

1. Bauer, R. C., Laney, A. O., Smith, R., Gerfen, J., Morrissette, J. J. D., Woyciechowski, S., Garbarini, J., Loomes, K. M., Krantz, I. D., Urban, Z., Gelb, B. D., Goldmuntz, E., Spinner, N. B. Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis. Hum. Mutat. 31: 594-601, 2010. 2. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., Davis, G. E. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci. 114: 2755-2773, 2001. 3. Boyer, J., Crosnier, C., Driancourt, C., Raynaud, N., Gonzales, M., Hadchouel, M., Meunier-Rotival, M. Expression of mutant JAGGED1 alleles in patients with Alagille syndrome. Hum. Genet. 116: 445-453, 2005.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

180 kDa

Applications Notes

6

Gene Name Synonym

Serpin family E member 1

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.