- Catalog number
- A03402
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- STC1 (Stanniocalcin 1), also called STC, which is encoded by the STC1 gene. By fluorescence in situ hybridization, Chang et al. (1998) mapped the STC1 gene to chromosome 8p21-p11.2. Wagner et al. (1995) found evidence of STC immunoreactivity in human kidney and serum, suggesting the existence of the hormone in mammals. Zhang et al. (1998) reported a constitutive expression of STC in terminally differentiated neurons. Bell et al. (2001) determined that STC1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices.
- Synonyms
- Interleukin-12 receptor subunit beta-1; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component; CD212; IL12RB1; IL12R, IL12RB
- Gene Name
- STC1
- Gene ID
- 6781
- UniProt
- P52823
- Host
- Rabbit
- Reactivity
- Human
- Cross Reactivity
- No cross-reactivity with other proteins.
- Immunogen
- E.coli-derived human Stanniocalcin 1/STC/STC1 recombinant protein (Position: V34-A247) .
- Clonality
- Polyclonal
- Applications
- IHC, ELISA
- Field of Research
- Cytokines, Immunology, Innate Immunity, Interleukins
- Purification
- Immunogen affinity purified.
- Concentration
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Function
- Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. .
- References & Citations
- 1. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., Davis, G. E. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci. 114: 2755-2773, 2001. 2. Chang, A. C.-M., Jeffrey, K. J., Tokutake, Y., Shimamoto, A., Neumann, A. A., Dunham, M. A., Cha, J., Sugawara, M., Furuichi, Y., Reddel, R. R. Human stanniocalcin (STC) : genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. Genomics 47: 393-398, 1998. 3. Wagner, G. F., Guiraudon, C. C., Milliken, C., Copp, D. H. Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. Proc. Nat. Acad. Sci. 92: 1871-1875, 1995. 4. Zhang, K., Westberg, J. A., Paetau, A., von Boguslawsky, K., Lindsberg, P., Erlander, M., Guo, H., Su, J., Olsen, H. S., Andersson, L. C. High expression of stanniocalcin in differentiated brain neurons. Am. J. Path. 153: 439-445, 1998.
- Storage Conditions
- At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
- Calculated Molecular Weight
- 73109 MW
- Observed Molecular Weight
- 75 kDa
- Gene Name Synonym
- Interleukin-12 receptor subunit beta-1
- Subcellular Location
- Membrane; Single-pass type I membrane protein.
- Protein Name
- Interleukin-12 receptor subunit beta-1
- Isotype
- Rabbit IgG
- Contents
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
