Anti-ADAR1/ADAR Antibody Picoband®

About this product

Boster Bio Anti-ADAR1/ADAR Antibody Picoband® catalog # A00869-2. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00869-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene. This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

Synonyms

Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; CD137; Tnfrsf9; Cd137; Ila; Ly63

Gene Name

ADAR

Gene ID

103

UniProt

P55265

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ADAR1/ADAR recombinant protein (Position: M1-E1152) .

Clonality

Polyclonal

Tissue Specificity

Expressed on the surface of activated T-cells.

Applications

WB, IHC, ICC, IF, ELISA

Field of Research

Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Cell Type Markers, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Lymphoid, Receptors, Stem Cells, T Lymphocytic Lineage, TNF Superfamily, Tumor Immunology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

References & Citations

1. Agranat, L., Raitskin, O., Sperling, J., Sperling, R. The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc. Nat. Acad. Sci. 105: 5028-5033, 2008. 2. Bass, B. L., Weintraub, H. An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55: 1089-1098, 1988. 3. Chao, S.-C., Huang, C.-Y., Yang, M.-H. A novel nonsense mutation of the DSRAD gene in a Taiwanese family with dyschromatosis symmetrica hereditaria. Europ. J. Derm. 16: 449-540, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

110 kDa

Gene Name Synonym

TNF receptor superfamily member 9

Subcellular Location

Membrane; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.