Anti-Ccl21 Antibody Picoband®

About this product

Boster Bio Anti-Ccl21 Antibody Picoband® catalog # A00765-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00765-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19) .

Synonyms

Muellerian-inhibiting factor; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS; AMH; MIF

Gene Name

Ccl21

Gene ID

298006

UniProt

Q5RJN3

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat Ccl21 recombinant protein (Position: S24-Q133) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Developmental Biology, Growth Factors/Hormones, Reproduction, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, TGF Beta

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

References & Citations

1. Dijkstra, I. M., Hulshof, S., van der Valk, P., Boddeke, H. W. G. M., Biber, K. Cutting edge: activity of human adult microglia in response to CC chemokine ligand 21. J. Immun. 172: 2744-2747, 2004. 2. Harhausen, D., Prinz, V., Ziegler, G., Gertz, K., Endres, M., Lehrach, H., Gasque, P., Botto, M., Stahel, P. F., Dirnagl, U., Nietfeld, W., Trendelenburg, G. CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia. J. Immun. 184: 6407-6417, 2010. 3. Hedrick, J. A., Zlotnik, A. Identification and characterization of a novel beta chemokine containing six conserved cysteines. J. Immun. 159: 1589-1593, 1997.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

59195 MW

Observed Molecular Weight

15 kDa

Applications Notes

6

Gene Name Synonym

Muellerian-inhibiting factor

Subcellular Location

Secreted.

Protein Name

Muellerian-inhibiting factor

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.