Anti-CPEB4 Antibody Picoband®

About this product

Boster Bio Anti-CPEB4 Antibody Picoband® catalog # A06139-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06139-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a sequence-specific RNA-binding protein that participates in translational control. CPEB4 is a member of the CPEB family, which includes CPEB1, CPEB2, CPEB3, and CPEB4, all of which share structure and sequence identity in the C-terminal RNA-binding domain (RBD) . CPEB4 has two domains: one that is structured for RNA binding and one that is unstructured and low complexity that has no known function.

Synonyms

Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR; DUSP3; VHR

Gene Name

CPEB4

Gene ID

80315

UniProt

Q17RY0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CPEB4 recombinant protein (Position: D3-N462) .

Clonality

Polyclonal

Tissue Specificity

Testis specific.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

References & Citations

1. Nagase, T., Kikuno, R., Hattori, A., Kondo, Y., Okumura, K., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 347-355, 2000. 2. Ortiz-Zapater, E., Pineda, D., Martinez-Bosch, N., Fernandez-Miranda, G., Iglesias, M., Alameda, F., Moreno, M., Eliscovich, C., Eyras, E., Real, F. X., Mendez, R., Navarro, P. Key contribution of CPEB4-mediated translational control to cancer progression. Nature Med. 18: 83-90, 2011. 3. Parras, A., Anta, H., Santos-Galindo, M., Swarup, V., Elorza, A., Nieto-Gonzalez, J. L., Pico, S., Hernandez, I. H., Diaz-Hernandez, J. I., Belloc, E., Rodolosse, A., Parikshak, N. N., Penagarikano, O., Fernandez-Chacon, R., Irimia, M., Navarro, P., Geschwind, D. H., Mendez, R., Lucas, J. J. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 560: 441-446, 2018.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

17828 MW

Observed Molecular Weight

90 kDa

Applications Notes

6

Gene Name Synonym

Dual specificity phosphatase 3

Subcellular Location

Nucleus.

Protein Name

Delta-1-pyrroline-5-carboxylate synthase

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.