Anti-RRM1 Antibody Picoband®

About this product

Boster Bio Anti-RRM1 Antibody Picoband® catalog # A01764-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01764-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

Synonyms

Semaphorin-3A; Semaphorin III; Sema III; SEMA3A; SEMAD

Gene Name

RRM1

Gene ID

6240

UniProt

P23921

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RRM1 recombinant protein (Position: D129-Q730) .

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Field of Research

Axonal Guidance Proteins, Cardiogenesis, Cardiovascular, Growth and Development, Hypertrophy, Neurology Process, Neuroscience, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.

References & Citations

1. Brissenden, J. E., Caras, I., Thelander, L., Francke, U. The structural gene for the M1 subunit of human ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. Exp. Cell Res. 174: 302-308, 1988. 2. Byrne, J. A., Smith, P. J. The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Hum. Genet. 91: 275-277, 1993. 3. Byrne, J., Smith, P. Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. Hum. Genet. 87: 376 only, 1991.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

90 kDa

Applications Notes

6

Gene Name Synonym

Semaphorin 3A

Subcellular Location

Secreted .

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.