Anti-SLAM/CD150/SLAMF1 Antibody

About this product

Boster Bio Anti-SLAM/CD150/SLAMF1 Antibody Picoband® catalog # A03988-2. Tested in ELISA, Flow Cytometry, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

A03988-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP) .

Synonyms

Intercellular adhesion molecule 2; ICAM-2; CD102; ICAM2

Gene Name

SLAMF1

Gene ID

6504

UniProt

Q13291

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SLAM/CD150/SLAMF1 recombinant protein (Position: K34-N213) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

Applications

IHC, Flow Cytometry, ELISA

Field of Research

Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

References & Citations

1. Chan, B., Lanyi, A., Song, H. K., Griesbach, J., Simarro-Grande, M., Poy, F., Howie, D., Sumegi, J., Terhorst, C., Eck, M. J. SAP couples Fyn to SLAM immune receptors. Nature Cell Biol. 5: 155-160, 2003. 2. Cocks, B. G., Chang, C.-C. J., Carballido, J. M., Yssel, H., de Vries, J. E., Aversa, G. A novel receptor involved in T-cell activation. Nature 376: 260-263, 1995. 3. Ferrante, P., Fusi, M. L., Saresella, M., Caputo, D., Biasin, M., Trabattoni, D., Salvaggio, A., Clerici, E., de Vries, J. E., Aversa, G., Cazzullo, C. L., Clerici, M. Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM) -expressing lymphocytes in acute multiple sclerosis. J. Immun. 160: 1514-1521, 1998.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

50 kDa

Applications Notes

6

Gene Name Synonym

Intercellular adhesion molecule 2

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Eukaryotic initiation factor 4A-I

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.