Anti-TRPM2 Antibody Picoband®

About this product

Boster Bio Anti-TRPM2 Antibody Picoband® catalog # A01013-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01013-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transient receptor potential cation channel subfamily M member 2, also known as TRPM2 is a protein that in humans is encoded by the TRPM2 gene. Using a cosmid/BAC contig, this gene is mapped to chromosome 21q22.3. The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Synonyms

Complement component C9; Complement component C9a; Complement component C9b; C9

Gene Name

TRPM2

Gene ID

7226

UniProt

O94759

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TRPM2 recombinant protein (Position: R398-Y1503) .

Clonality

Polyclonal

Tissue Specificity

Plasma.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Complement, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

References & Citations

1. Du, J., Xie, J., Yue, L. Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc. Nat. Acad. Sci. 106: 7239-7244, 2009. 2. Farooqi, A. A., Javeed, M. K., Javed, Z., Riaz, A. M., Mukhtar, S., Minhaj, S., Abbas, S., Bhatti, S. TRPM channels: same ballpark, different players, and different rules in immunogenetics. Immunogenetics 63: 773-787, 2011. 3. McQuillin, A., Bass, N. J., Kalsi, G., Lawrence, J., Puri, V., Choudhury, K., Detera-Wadleigh, S. D., Curtis, D., Gurling, H. M. D. Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Molec. Psychiat. 11: 134-142, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

63173 MW

Observed Molecular Weight

171 kDa

Applications Notes

6

Gene Name Synonym

Complement component C9

Subcellular Location

Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.