- Catalog number
- A00719-2
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- Mucin 5B (MUC5B/Muc5b) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
- Synonyms
- Folliculin; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; FLCN; BHD
- Gene Name
- MUC5B
- Gene ID
- 727897
- UniProt
- Q9HC84
- Host
- Rabbit
- Reactivity
- Human
- Cross Reactivity
- No cross-reactivity with other proteins.
- Immunogen
- E.coli-derived human MUC5B recombinant protein (Position: A5688-V5762) .
- Clonality
- Polyclonal
- Tissue Specificity
- Skeletal muscle, heart, colon, testis, ovary and pancreas.
- Applications
- IHC, ELISA
- Field of Research
- Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels
- Purification
- Immunogen affinity purified.
- Concentration
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Function
- May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
- References & Citations
- 1. Desseyn, J.-L., Aubert, J.-P., van Seuningen, I., Porchet, N., Laine, A. Genomic organization of the 3-prime region of the human mucin gene MUC5B. J. Biol. Chem. 272: 16873-16883, 1997. 2. Desseyn, J.-L., Buisine, M. P., Porchet, N., Aubert, J.-P., Laine, A. Genomic organization of the human mucin gene MUC5B, cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem. 273: 30157-30164, 1998. 3. Desseyn, J.-L., Guyonnet-Duperat, V., Porchet, N., Aubert, J.-P., Laine, A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat: structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272: 3168-3178, 1997.
- Storage Conditions
- At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
- Calculated Molecular Weight
- 28994 MW
- Observed Molecular Weight
- 70 kDa
- Gene Name Synonym
- Folliculin
- Subcellular Location
- Cytoplasm. Nucleus.
- Protein Name
- Emerin
- Isotype
- Rabbit IgG
- Contents
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
