Anti-KHSRP Antibody Picoband® (monoclonal, 4F10D2)

About this product

Boster Bio Anti-KHSRP Antibody Picoband® (monoclonal, 4F10D2) catalog # M02770-3. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

M02770-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene. The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization.

Synonyms

N-myc-interactor; Nmi; N-myc and STAT interactor; NMI

Gene Name

KHSRP

Gene ID

8570

UniProt

Q92945

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human KHSRP recombinant protein (Position: D116-R478) .

Clonality

Monoclonal

Clone

Clone: 4F10D2

Tissue Specificity

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Applications

WB, ICC, IF, Flow Cytometry

Field of Research

Cytoskeleton, Cytoskeleton/ECM, Motor Proteins, Myosin, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

References & Citations

1. Briata, P., Forcales, S. V., Ponassi, M., Corte, G., Chen, C.-Y., Karin, M., Puri, P. L., Gherzi, R. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molec. Cell 20: 891-903, 2005. 2. Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G., Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J. Biol. Chem. 271: 31679-31687, 1996. 3. Gherzi, R., Lee, K.-Y., Briata, P., Wegmuller, D., Moroni, C., Karin, M., Chen, C.-Y. A KH domain RNA binding protein, KSRP, promotes ARE-ed mRNA turnover by recruiting the degradation machinery. Molec. Cell 14: 571-583, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

82 kDa

Applications Notes

6

Gene Name Synonym

N-myc (and STAT) interactor

Subcellular Location

Cytoplasm.

Isotype

Mouse IgG2b

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.