Anti-Acid phosphatase/ACP1 Antibody Picoband®

About this product

Boster Bio Anti-Acid phosphatase/ACP1 Antibody Picoband® catalog # A02167-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02167-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene. The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Synonyms

Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA (2) ; PAF 2-acylhydrolase; PLA2G7; PAFAH

Gene Name

ACP1

Gene ID

52

UniProt

P24666

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Acid phosphatase/ACP1 recombinant protein (Position: M1-H158) .

Clonality

Polyclonal

Tissue Specificity

Plasma.

Applications

WB, ELISA

Field of Research

Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Secreted Molecules

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

References & Citations

1. Arnaud, J., Vavrusa, B., Sevin, J., Constans, J. Human red-cell acid phosphatase (ACP1) : a new mutant (ACP1*KUK) detected by isoelectric focusing, kinetics of thermostability and substrate activity. Hum. Hered. 39: 288-293, 1989. 2. Arnaud, J., Vavrusa, B., Wiederanders, G., Constans, J. Human red-cell acid phosphatase (ACP1) : kinetic and thermodynamic characterization of the KUK variant. Hum. Hered. 42: 140-142, 1992. 3. Beemer, F. A., van der Heiden, C., Van Hemel, J. O., Jansen, M. Letter to the editors. (Letter) Clin. Genet. 24: 151, 1983.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

63692 MW

Observed Molecular Weight

17 kDa

Gene Name Synonym

Phospholipase A2 group VII

Subcellular Location

Secreted, extracellular space.

Protein Name

Sentrin-specific protease 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.