Anti-MX1 Antibody Picoband®

About this product

Boster Bio Anti-MX1 Antibody Picoband® catalog # A00849-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00849-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. This gene encodes a guanosine triphosphate (GTP) -metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.

Synonyms

Complement component C7; C7

Gene Name

MX1

Gene ID

4599

UniProt

P20591

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MX1 recombinant protein (Position: K435-Q621) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Angiogenesis, Cancer, Cardiovascular, Developmental Biology, Embryogenesis, Growth Factors, Growth Factors/Hormones, Lineage Specification, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

References & Citations

1. Bigham, A. W., Buckingham, K. J., Husain, S., Emond, M. J., Bofferding, K. M., Gildersleeve, H., Rutherford, A., Astakhova, N. M., Perelygin, A. A., Busch, M. P., Murray, K. O., Sejvar, J. J., Green, S., Kriesel, J., Brinton, M. A., Bamshad, M. Host genetic risk factors for West Nile virus infection and disease progression. PLoS One 6: e24745, 2011. Note: Electronic Article. 2. Horisberger, M. A., Wathelet, M., Szpirer, J., Szpirer, C., Islam, Q., Levan, G., Huez, G., Content, J. cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene. Somat. Cell Molec. Genet. 14: 123-131, 1988. 3. Huber, P., Aebi, M., Grob, R., Pravtcheva, D., Ruddle, F., Haller, O. Chromosomal localization of two human Mx genes. (Abstract) Experientia 44: A84 only, 1988.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

55914 MW

Observed Molecular Weight

76 kDa

Applications Notes

6

Gene Name Synonym

Complement C7

Subcellular Location

Secreted.

Protein Name

Protein argonaute-1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.