Anti-TRPV6 Antibody Picoband®

About this product

Boster Bio Anti-TRPV6 Antibody Picoband® catalog # A02139-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02139-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

TRPV6 (Transient Receptor Potential Cation Channel Subfamily V Member 6), also known as ECAC2, CAT1 or CATL, a membrane calcium channel which is responsible for the first step in calcium absorption in the intestine. TRPV6 is a member of the Transient receptor potential (TRP) family of membrane proteins. Using FISH, Peng et al. (2000) mapped the TRPV6 gene to chromosome 7q33-q34. Peng et al. (2000) determined that TRPV6 mediates calcium uptake independent of sodium, chloride, and hydrogen; however, calcium influx was higher at alkaline rather than acidic pH. Functional analysis by Peng et al. (2001) indicated that TRPV5 mediates greater calcium uptake than TRPV6. They concluded that TRPV5 and TRPV6 are calcium-selective channels and share a common ancestral gene.

Synonyms

DNA repair protein XRCC2; X-ray repair cross-complementing protein 2; Xrcc2

Gene Name

TRPV6

Gene ID

55503

UniProt

Q9H1D0

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TRPV6 recombinant protein (Position: A15-I765) .

Clonality

Polyclonal

Tissue Specificity

Expressed at low level in somatic tissues and at high level in testis.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

References & Citations

1. Peng, J.-B., Brown, E. M., Hediger, M. A. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76: 99-109, 2001. 2. Peng, J.-B., Chen, X.-Z., Berger, U. V., Weremowicz, S., Morton, C. C., Vassilev, P. M., Brown, E. M., Hediger, M. A. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278: 326-332, 2000. 3. Peng, J.-B., Zhuang, L., Berger, U. V., Adam, R. M., Williams, B. J., Brown, E. M., Hediger, M. A., Freeman, M. R. CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun. 282: 729-734, 2001.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

83 kDa

Applications Notes

6

Gene Name Synonym

X-ray repair complementing defective repair in Chinese hamster cells 2

Subcellular Location

Nucleus.

Protein Name

DNA repair protein XRCC2

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.