Anti-BI-1/TMBIM6 Antibody Picoband®

About this product

Boster Bio Anti-BI-1/TMBIM6 Antibody Picoband® catalog # A05462. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A05462

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene. Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma.

Synonyms

Prion-like protein doppel; PrPLP; Prion protein 2; PRND; DPL; UNQ1830/PRO3443

Gene Name

TMBIM6

Gene ID

7009

UniProt

P55061

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human BI-1/TMBIM6, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level) .

Applications

IF, IHC, ICC, WB

Field of Research

Neurodegenerative Disease, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Required for normal acrosome reaction and for normal male fertility (By similarity) . Can bind Cu (2+) (PubMed:15218028, PubMed:20411530) .

References & Citations

1. Bailly-Maitre, B., Fondevila, C., Kaldas, F., Droin, N., Luciano, F., Ricci, J.-E., Croxton, R., Krajewska, M., Zapata, J. M., Kupiec-Weglinski, J. W., Farmer, D., Reed, J. C. Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. Proc. Nat. Acad. Sci. 103: 2809-2814, 2006. 2. Carrara, G., Saraiva, N., Gubser, C., Johnson, B. F., Smith, G. L. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. J. Biol. Chem. 287: 15896-15905, 2012. 3. Gross, M. B. Personal Communication. Baltimore, Md. 3/22/2016.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

39411 MW

Observed Molecular Weight

35 kDa

Gene Name Synonym

Prion like protein doppel

Subcellular Location

Cell membrane.

Protein Name

Zinc finger protein Helios

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.